Mixed
Targeting mitochondrial dysfunction through dietary supplements (e.g., NAD+ precursors, antioxidants) and pharmacological agents shows promise in preclinical models but lacks robust clinical translation due to issues with stability and efficacy.
While specific mitochondrial supplements and drugs are being researched, current clinical evidence is limited. The most accessible way to support mitochondrial health remains regular physical activity, which promotes mitochondrial biogenesis and function, alongside a balanced diet that provides necessary nutrients for mitochondrial function.
These small molecular drugs can either exert their effects directly on the mitochondria or influence the organelle indirectly by binding to their cytosolic or nuclear regulators. ... However, the clinical translation is still limited, including unstable mitochondrial vitality, inefficient cellular internalization, and transient therapeutic effects, which collectively hinder the medical practice.
Why this rating
The paper is a review summarizing preclinical and limited clinical data; it does not present new primary clinical trial results.
Source
Mitochondrial dysfunction: mechanisms and advances in therapy
Zong Yao et al. · Signal Transduction and Targeted Therapy · 2024
DOI 10.1038/s41392-024-01839-8
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