Research
Mixed
Mitochondrial transplantation, involving the transfer of healthy mitochondria to damaged cells, is a promising preclinical therapy for various diseases but faces challenges in clinical translation due to unstable vitality and transient effects.
Mitochondrial transplantation is an experimental therapy currently limited to research settings and specific clinical trials. It is not a standard treatment. Patients interested in this therapy should consult with their healthcare provider about available clinical trials.
ModerateQualifiesMEDIUM confidence
Advanced intervention such as using healthy mitochondria to replenish or replace damaged mitochondria, has shown promise in preclinical trials of various diseases. ... However, the clinical translation is still limited, including unstable mitochondrial vitality, inefficient cellular internalization, and transient therapeutic effects, which collectively hinder the medical practice.
Why this rating
Based on preclinical trials and limited clinical observations (e.g., pediatric ECMO patients), but not large-scale clinical trials.
Source
Mitochondrial dysfunction: mechanisms and advances in therapy
Zong Yao et al. · Signal Transduction and Targeted Therapy · 2024
DOI 10.1038/s41392-024-01839-8
narrative_reviewCited 945×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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