Hormonal
Phentermine monotherapy produces significantly higher rates of ≥5% weight loss compared to other anti-obesity medications (phentermine/topiramate, liraglutide, naltrexone/bupropion, lorcaserin, orlistat) over a 6-month period.
If you are struggling with obesity and lifestyle changes alone haven't worked, phentermine (up to 37.5mg daily) combined with a structured diet and exercise program is likely to produce better weight loss results than other common prescription weight loss drugs over a 6-month period. Ensure you are monitored by a doctor to manage any side effects.
At each visit, after adjustment for age, sex, and baseline body weight, phentermine use was associated with a significantly higher prevalence of ≥5% weight loss than the use of the other AOMs, except for liraglutide.
Why this rating
Real-world retrospective study with significant dropout rates and lack of randomization, though adjusted for covariates.
Source
Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice
Ji-Eun Song et al. · Drug Design Development and Therapy · 2024
DOI 10.2147/dddt.s445415
More from this paper
- Liraglutide is the only other anti-obesity medication that does not significantly differ in efficacy from phentermine for achieving ≥5% weight loss over 6 months.Moderate
- Naltrexone/bupropion, lorcaserin, and orlistat are significantly less effective than phentermine for achieving ≥5% weight loss over 6 months.Moderate
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