Research
Hormonal
Liraglutide is the only other anti-obesity medication that does not significantly differ in efficacy from phentermine for achieving ≥5% weight loss over 6 months.
Liraglutide (up to 3mg daily) is a viable alternative to phentermine for weight loss, showing similar efficacy in achieving 5% weight loss over 6 months when combined with lifestyle changes.
ModerateQualifiesMEDIUM confidence
The liraglutide group did not significantly differ in the weight loss it induced from the phentermine group at any of the time points assessed
Why this rating
Same study limitations as N1.
Source
Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice
Ji-Eun Song et al. · Drug Design Development and Therapy · 2024
DOI 10.2147/dddt.s445415
cohort · n=205Cited 16×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Phentermine monotherapy produces significantly higher rates of ≥5% weight loss compared to other anti-obesity medications (phentermine/topiramate, liraglutide, naltrexone/bupropion, lorcaserin, orlistat) over a 6-month period.Moderate
- Naltrexone/bupropion, lorcaserin, and orlistat are significantly less effective than phentermine for achieving ≥5% weight loss over 6 months.Moderate
Related findings · Hormonal
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- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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