Research
Hormonal
Naltrexone/bupropion, lorcaserin, and orlistat are significantly less effective than phentermine for achieving ≥5% weight loss over 6 months.
Naltrexone/bupropion, lorcaserin, and orlistat are less likely to produce significant weight loss (≥5%) compared to phentermine over 6 months when combined with lifestyle changes.
ModerateRefutesMEDIUM confidence
At the 6 month time point, the ORs for each AOM group, compared with the phentermine group, were as follows: ... naltrexone/bupropion, 0.089 (95% CI, 0.022–0.355); lorcaserin, 0.221 (95% CI, 0.074–0.661); and orlistat, 0.281 (95% CI, 0.092–0.863).
Why this rating
Same study limitations.
Source
Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice
Ji-Eun Song et al. · Drug Design Development and Therapy · 2024
DOI 10.2147/dddt.s445415
cohort · n=205Cited 16×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Phentermine monotherapy produces significantly higher rates of ≥5% weight loss compared to other anti-obesity medications (phentermine/topiramate, liraglutide, naltrexone/bupropion, lorcaserin, orlistat) over a 6-month period.Moderate
- Liraglutide is the only other anti-obesity medication that does not significantly differ in efficacy from phentermine for achieving ≥5% weight loss over 6 months.Moderate
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