Research
Hormonal
Selenium-dependent selenoproteins (specifically deiodinases and glutathione peroxidases) are essential for thyroid hormone activation/inactivation and protecting thyroid cells from oxidative damage during hormone synthesis.
Support thyroid health with both iodine and selenium. Selenium is required for the enzymes that activate thyroid hormones and protect the thyroid gland from damage during hormone production.
StrongSupportsVERY_HIGH confidence
Several selenoproteins participate in the protection of thyrocytes from damage by H2O2 produced for thyroid hormone biosynthesis. Iodothyronine deiodinases are selenoproteins contributing to systemic or local thyroid hormone homeostasis.
Why this rating
Strong evidence from genetic knockout models, biochemical characterization, and clinical observation of endemic cretinism.
Source
Selenium, the Thyroid, and the Endocrine System
Josef Köhrle et al. · Endocrine Reviews · 2005
DOI 10.1210/er.2001-0034
narrative_reviewCited 519×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Selenium is preferentially retained and redistributed to endocrine tissues (thyroid, adrenals, pituitary, testes, ovary) and the brain during nutritional depletion, prioritizing thyroid hormone homeostasis and cellular defense over other organs.Good
- Selenium status modulates the expression and activity of selenoproteins that regulate transcription by redox-sensitive nuclear hormone receptors, linking selenium metabolism to broader endocrine signaling.Good
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