Research
Hormonal
Selenium status modulates the expression and activity of selenoproteins that regulate transcription by redox-sensitive nuclear hormone receptors, linking selenium metabolism to broader endocrine signaling.
Maintain adequate selenium levels to support the body's redox balance, which influences how hormones interact with cells and regulate gene expression.
GoodQualifiesHIGH confidence
Selenoproteins such as thioredoxin reductases constitute the link between the Se metabolism and the regulation of transcription by redox sensitive ligand-modulated nuclear hormone receptors. Hormones and growth factors regulate the expression of selenoproteins and, conversely, Se supply modulates hormone actions.
Why this rating
Based on biochemical and cellular studies described in the review.
Source
Selenium, the Thyroid, and the Endocrine System
Josef Köhrle et al. · Endocrine Reviews · 2005
DOI 10.1210/er.2001-0034
narrative_reviewCited 519×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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