Research
Energy balance
Caloric restriction reduces oxidative stress and enhances mitochondrial biogenesis, leading to mitochondria that are more efficient in ATP production and generate less ROS.
Focus on reducing caloric intake moderately (20-40%) to improve mitochondrial health. This leads to better energy production and less cellular damage over time.
GoodSupportsHIGH confidence
CR reduces oxidative stress and enhances mitochondrial biogenesis in order to produce mitochondria that are more efficient in ATP production, have optimal oxidative capacity, and generate less ROS.
Why this rating
Supported by the CALERIE trial data cited in the paper.
Source
Mitochondrial Aging and Age-Related Dysfunction of Mitochondria
Dimitry A. Chistiakov et al. · BioMed Research International · 2014
DOI 10.1155/2014/238463
narrative_reviewCited 496×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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