Micronutrients & recovery
SIRT1 plays a complex, context-dependent role in atherosclerosis where tissue-specific overexpression can be protective, but whole-body overexpression in the context of high-fat diets may exacerbate the disease.
Do not assume that boosting SIRT1 (e.g., via high-dose resveratrol or NMN) is always beneficial for heart health, especially if you have existing metabolic issues like high cholesterol or obesity. The paper warns that whole-body SIRT1 activation can worsen lipid profiles in high-fat diet contexts. Consult a physician before using sirtuin activators if you have metabolic syndrome.
However, whole-body SIRT1 overexpressors that were placed on an atherogenic diet to induce plaque formation had worse lipid profiles and more severe atherosclerosis than wild-type mice on the same diet.
Why this rating
Based on specific mouse model studies (ApoE knockout, whole-body overexpressors).
Source
Sirtuins and NAD <sup>+</sup> in the Development and Treatment of Metabolic and Cardiovascular Diseases
Alice E. Kane et al. · Circulation Research · 2018
DOI 10.1161/circresaha.118.312498
More from this paper
- Upregulation of SIRT1 activity via STACs or NAD+ boosters (NR, NMN) protects against cardiovascular aging phenotypes including endothelial dysfunction, atherosclerosis, and ischemia-reperfusion injury by modulating transcription factors and antioxidant pathways.Moderate
- NAD+ boosters (specifically NMN and NR) and SIRT1 activators (like resveratrol) improve angiogenesis and endothelial function in aging models by restoring the NAD+-SIRT1 axis.Moderate
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