Micronutrients & recovery
NAD+ boosters (specifically NMN and NR) and SIRT1 activators (like resveratrol) improve angiogenesis and endothelial function in aging models by restoring the NAD+-SIRT1 axis.
Aging is associated with reduced blood flow and capillary density. This research suggests that boosting NAD+ (via precursors like NMN or NR) or activating SIRT1 (via exercise or STACs) may help restore blood vessel growth and function. This could potentially improve endurance and mobility in older adults, though human clinical results are still pending.
Increasing the hydrogen sulfide (H2S)-NAD+-SIRT1 axis in endothelial cells, either with NaHS to boost H2S, NMN to boost NAD+, or with exercise, causes SIRT1-dependent inhibition of Notch intracellular domain (NICD), which results in increased sprouting angiogenesis.
Why this rating
Supported by multiple animal studies (mice, rats, zebrafish) showing increased capillary density and endurance.
Source
Sirtuins and NAD <sup>+</sup> in the Development and Treatment of Metabolic and Cardiovascular Diseases
Alice E. Kane et al. · Circulation Research · 2018
DOI 10.1161/circresaha.118.312498
More from this paper
- Upregulation of SIRT1 activity via STACs or NAD+ boosters (NR, NMN) protects against cardiovascular aging phenotypes including endothelial dysfunction, atherosclerosis, and ischemia-reperfusion injury by modulating transcription factors and antioxidant pathways.Moderate
- SIRT1 plays a complex, context-dependent role in atherosclerosis where tissue-specific overexpression can be protective, but whole-body overexpression in the context of high-fat diets may exacerbate the disease.Moderate
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