Mixed
Accumulation of Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) driven by oxidative stress causes protein cross-linking and aggregation, leading to cellular dysfunction, damage, and death, which are key mechanisms in aging and age-related chronic diseases.
Aging and chronic diseases are linked to the accumulation of damaged proteins (ALEs/AGEs) caused by oxidative stress. Strategies that support the body's antioxidant systems and protein quality control (like caloric restriction or specific nutrient supplementation mentioned in the paper) may help delay these processes.
However, elevated ALE and AGE production leads to protein cross-linking and aggregation resulting in an alteration in cell signaling and functioning which causes cell damage and death. This is implicated in aging and various age-related chronic pathologies such as inflammation, neurodegenerative diseases, atherosclerosis, and vascular complications of diabetes mellitus.
Why this rating
Based on a review of multiple animal models and human studies, though it is a review article rather than a single clinical trial.
Source
Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases
Nurbubu T. Moldogazieva et al. · Oxidative Medicine and Cellular Longevity · 2019
DOI 10.1155/2019/3085756
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