Research
Energy balance
Intermittent fasting (IF) and time-restricted feeding (TRF) reduce oxidative stress and inflammation in Type 2 Diabetes by activating AMPK and SIRT3, which promotes autophagy and mitochondrial biogenesis.
Consider time-restricted feeding by limiting your eating window to 8-10 hours per day. If using intermittent fasting, restrict energy intake by 60% on 2-3 days a week. Monitor blood glucose closely, especially if taking diabetes medication, to avoid hypoglycemia.
ModerateSupportsMEDIUM confidence
Intermittent fasting (IF) involves a 60% or more energy restriction for 2–3 days a week or alternate-day fasting, while time-restricted feeding (TRF) limits the daily eating window to 8–10 h [74]. IF and TRF exhibit similar effects, counteracting oxidative stress and insulin resistance [75]. Fasting and CR exert their beneficial effects through the activation of adenosine monophosphate-activated protein kinase (AMPK)... Sirtuin 3 (SIRT3)... plays a crucial role in these strategies [79].
Why this rating
Based on a review of mouse models and general physiological mechanisms rather than large-scale human T2DM trials.
Source
Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications
Alfredo Caturano et al. · Current Issues in Molecular Biology · 2023
DOI 10.3390/cimb45080420
narrative_reviewCited 490×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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