Mixed
Administering a specialized high-protein oral nutritional supplement containing beta-hydroxy-beta-methylbutyrate (HP-HMB) to malnourished, older adults (≥65 years) hospitalized for acute medical conditions significantly reduces 90-day post-discharge mortality compared to placebo.
For older adults (65+) who are malnourished and hospitalized for heart or lung conditions, starting a high-protein supplement with HMB immediately upon admission and continuing it for 3 months after discharge can significantly lower the risk of death. This intervention is most effective when started early (within 72 hours) and continued post-discharge.
However, the 90-day mortality rate was significantly lower with HP-HMB relative to placebo, 4.8% and 9.7% (p = 0.018), respectively... Initiation of HP-HMB during hospitalization and continuation postdischarge resulted in a significantly lower mortality rate.
Why this rating
Large multicenter randomized controlled trial (n=652) with double-blind design, though limited by specific exclusion criteria (no diabetes/cancer).
Source
Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial
Nicolaas E.P. Deutz et al. · Clinical Nutrition · 2016
DOI 10.1016/j.clnu.2015.12.010
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →