Research
Hormonal
Histidine supplementation is inappropriate for patients with liver disease due to the risk of hepatic enlargement and increased blood ammonia and glutamine levels.
If you have liver disease, do not take histidine supplements. The paper indicates this can cause your liver to enlarge and increase toxic ammonia levels in your blood. Stick to dietary sources unless advised otherwise by your doctor.
GoodRefutesHIGH confidence
Of concern should be findings of hepatic enlargement and increases in ammonia and glutamine and of decrease in branched-chain amino acids (valine, leucine, and isoleucine) in blood plasma indicating that HIS supplementation is inappropriate in patients with liver disease.
Why this rating
Based on a review of metabolic pathways and observed plasma changes, though specific clinical trial data for liver patients is not detailed in the abstract.
Source
Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement
Milan Holeček · Nutrients · 2020
DOI 10.3390/nu12030848
narrative_reviewCited 458×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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