Research
Energy balance
Histidine-containing dipeptides (Carnosine and Anserine) act as powerful intracellular pH buffers that attenuate pH changes in muscles during anaerobic exercise.
Carnosine and anserine help your muscles handle the acidity of intense exercise. This is why they are often studied for performance benefits.
GoodSupportsHIGH confidence
Therefore, HIS-CD, such as CAR and anserine, act as powerful buffers and attenuate changes in intracellular pH in muscles during anaerobic exercise [11].
Why this rating
Well-established biochemical property cited with multiple references.
Source
Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement
Milan Holeček · Nutrients · 2020
DOI 10.3390/nu12030848
narrative_reviewCited 458×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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