Research
Hormonal
SIRT3 polymorphisms are associated with human longevity, with specific variants being more common in centenarians.
Genetic variants in SIRT3 may play a minor role in human longevity, but evidence is inconsistent. Lifestyle interventions like calorie restriction and exercise remain the most reliable way to influence healthspan.
ModerateQualifiesMEDIUM confidence
SIRT3 is the only sirtuin for which evidence exists that it can influence longevity in humans. It was shown that a certain polymorphism in SIRT3 gene can be found more often in long-lived people.
Why this rating
Initial findings in small Italian population were not confirmed in larger studies.
Source
Sirtuins, a promising target in slowing down the ageing process
Wioleta Grabowska et al. · Biogerontology · 2017
DOI 10.1007/s10522-017-9685-9
narrative_reviewCited 457×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Sirtuin levels decrease with age in various tissues, and this decrease is associated with increased DNA damage, oxidative stress, and frailty.Good
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