Research
Hormonal
Sirtuin levels decrease with age in various tissues, and this decrease is associated with increased DNA damage, oxidative stress, and frailty.
Sirtuin levels naturally decline with age, contributing to frailty and DNA damage. However, lifestyle interventions like calorie restriction and exercise can help maintain or increase sirtuin levels, supporting healthspan.
GoodSupportsHIGH confidence
The level of SIRT1 decreases in the liver with age... Age-dependent decrease in the level of SIRT1 was observed also in the arteries... lower levels of SIRT1 and SIRT3 were associated with frailty.
Why this rating
Consistent observation across multiple tissues and species.
Source
Sirtuins, a promising target in slowing down the ageing process
Wioleta Grabowska et al. · Biogerontology · 2017
DOI 10.1007/s10522-017-9685-9
narrative_reviewCited 457×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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