Energy balance
Calorie restriction extends healthspan and lifespan in model organisms by increasing sirtuin levels, which medates DNA repair, genomic stability, and metabolic regulation.
Calorie restriction is the most proven non-pharmacological method to extend lifespan and healthspan, largely by boosting sirtuin activity. While sirtuin activators are being researched, current evidence strongly supports lifestyle interventions like diet and exercise to naturally increase sirtuin levels and improve metabolic health.
Calorie restriction (CR) is so far the only effective way to extend lifespan without genetic or pharmacological intervention... The level of almost all sirtuins, except SIRT4, increases as an effect of calorie restriction... Therefore, it is believed that sirtuins mediate beneficial effects elicited by such diet.
Why this rating
Strong evidence in yeast, worms, flies, and mice; human data is observational/correlational regarding sirtuin levels and healthspan.
Source
Sirtuins, a promising target in slowing down the ageing process
Wioleta Grabowska et al. · Biogerontology · 2017
DOI 10.1007/s10522-017-9685-9
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