Research
Macro partitioning
Trans fatty acid intake is positively associated with coronary disease risk, supporting guidelines to avoid them.
Avoid trans fats. This large review confirms that higher intake of trans fatty acids is associated with an increased risk of coronary disease, supporting current guidelines to avoid them.
GoodSupportsMEDIUM confidence
total dietary trans fatty acid intake was positively associated with coronary disease risk in our meta-analysis, which is in line with the present guidelines that support avoidance of trans fats.
Why this rating
Meta-analysis of observational studies, though limited by fewer studies on trans fats.
Source
Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk
Rajiv Chowdhury et al. · Annals of Internal Medicine · 2014
DOI 10.7326/m13-1788
Meta-analysis · 72 studiesCited 1,144×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids (omega-3 and omega-6) or low consumption of total saturated fats for coronary risk reduction.Good
- Supplementation with long-chain omega-3 and omega-6 polyunsaturated fatty acids does not statistically significantly reduce the risk of coronary outcomes in randomized controlled trials.Good
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
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