Research
Mixed
Supplementation with long-chain omega-3 and omega-6 polyunsaturated fatty acids does not statistically significantly reduce the risk of coronary outcomes in randomized controlled trials.
Taking omega-3 supplements (0.3-6g/day) does not appear to significantly reduce the risk of coronary disease based on this large review of randomized trials. While some observational studies suggested benefits, the higher-quality trial data did not confirm a significant protective effect.
GoodRefutesHIGH confidence
our meta-analysis of randomized trials of long-chain omega-3 and omega-6 polyunsaturated fatty acid supplements suggests that supplementation with these nutrients does not statistically significantly reduce the risk for coronary outcomes.
Why this rating
Meta-analysis of 27 RCTs with over 100,000 participants.
Source
Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk
Rajiv Chowdhury et al. · Annals of Internal Medicine · 2014
DOI 10.7326/m13-1788
Meta-analysis · 72 studiesCited 1,144×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids (omega-3 and omega-6) or low consumption of total saturated fats for coronary risk reduction.Good
- Trans fatty acid intake is positively associated with coronary disease risk, supporting guidelines to avoid them.Good
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