Energy balance
Skeletal muscle SIRT3 expression is dynamically regulated by environmental signals: it increases with exercise training, caloric restriction, and fasting, but decreases with high-fat diet consumption.
Your skeletal muscle contains a regulator called SIRT3 that acts as a sensor for your lifestyle. Regular exercise, fasting, or caloric restriction can increase the levels of this protein, which helps coordinate energy metabolism. Conversely, a chronic high-fat diet can decrease these levels. This suggests that maintaining metabolic health involves dynamic adjustments to your diet and activity levels.
SIRT3 responds dynamically to both exercise and nutritional signals in skeletal muscle to coordinate downstream molecular responses. ... SIRT3 expression increases by fasting and caloric restriction, yet it is decreased by high-fat diet.
Why this rating
Strong experimental evidence using multiple mouse models (wild-type, knockout, various diets/exercise protocols) with consistent Western blot and mRNA data.
Source
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
Orsolya M Palacios et al. · Aging · 2009
DOI 10.18632/aging.100075
More from this paper
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →