Research
Energy balance
SIRT3 is required for the full activation of AMPK and CREB, and the subsequent upregulation of PGC-1α expression in skeletal muscle.
SIRT3 acts as an upstream activator for other key metabolic regulators like AMPK and PGC-1α. Without sufficient SIRT3, the muscle's ability to activate these energy-sensing and mitochondrial-building pathways is significantly reduced.
GoodSupportsHIGH confidence
Conversely in SIRT3 knockout mice, we find that the phosphorylation of both AMPK and CREB and the expression of PGC-1α are down regulated, suggesting that these key cellular factors may be important components of SIRT3-mediated biological signals in vivo.
Why this rating
Clear evidence from knockout mouse models showing reduced phosphorylation of key enzymes.
Source
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
Orsolya M Palacios et al. · Aging · 2009
DOI 10.18632/aging.100075
mechanism_onlyCited 479×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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