Hormonal
Exercise training improves insulin sensitivity in insulin-resistant individuals by increasing lipid oxidation and reducing intramuscular lipid species (ceramides and diacylglycerol) that inhibit insulin signaling.
If you are insulin resistant, your muscles might be storing fat in the wrong places (like inside the muscle cell), which blocks insulin. Regular exercise helps your muscles burn this fat for energy. This 'cleaning' process removes the specific fats that block insulin signals, making your body more sensitive to insulin over time.
The findings by Bruce et al. (2006) suggest that exercise training may improve muscle insulin sensitivity by increasing the proportion of lipids targeted for oxidation, thereby reducing the accumulation of lipid species that are known to inhibit insulin signal transduction...
Why this rating
Supported by specific human studies cited (Bruce et al. 2006, Goodpaster et al. 2003) showing strong correlation between lipid oxidation and insulin sensitivity.
Source
Exercise training‐induced improvements in insulin action
John A. Hawley et al. · Acta Physiologica · 2007
DOI 10.1111/j.1748-1716.2007.01783.x
More from this paper
- Repeated exercise training produces persistent improvements in skeletal muscle insulin sensitivity through up-regulation of GLUT4, AMPK, and lipid oxidation pathways, whereas a single bout of exercise only provides a transient (approx. 48h) insulin-sensitizing effect.Good
- Exercise training restores impaired insulin-stimulated PI3-kinase (PI3K) activity in skeletal muscle, which is typically decreased in insulin-resistant subjects and type 2 diabetes patients.Good
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