Micronutrients & recovery
Caloric restriction extends life span in model organisms by inducing autophagy, a process essential for clearing damaged organelles and proteins.
Caloric restriction extends life in animals by triggering autophagy, which cleans out damaged cellular parts. While strict dieting is hard to maintain, the paper suggests that pharmacologic agents like rapamycin or spermidine might mimic these benefits by inducing autophagy without the discomfort of starvation. Future research aims to identify safe drugs that activate this recycling process.
Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient signaling converge on the induction of autophagy...
Why this rating
Strong evidence from multiple model organisms (yeast, worms, flies, mice) showing that inhibiting autophagy abolishes life span extension.
Source
Essential role for autophagy in life span extension
Frank Madeo et al. · Journal of Clinical Investigation · 2015
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