Research
Micronutrients & recovery
Genetic overexpression of autophagy-related proteins (e.g., ATG5, LC3/ATG8) is sufficient to extend life span in model organisms.
In animals, genetically boosting autophagy proteins extends life. This proves that enhancing the body's natural cleanup system is enough to live longer. However, this is not a practical human intervention yet, as it requires genetic modification.
GoodSupportsHIGH confidence
Genetic manipulations solely designed to increase autophagy are able to extend life span in several species. For instance, transgene-enforced overexpression of the pro-autophagic protein ATG5 enhanced the life span of mice... brain-specific overexpression of LC3/ATG8 in D. melanogaster is sufficient to prolong life span.
Why this rating
Strong evidence in flies and mice, but not yet applicable to humans.
Source
Essential role for autophagy in life span extension
Frank Madeo et al. · Journal of Clinical Investigation · 2015
narrative_reviewCited 443×
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