Energy balance
Modest weight loss of 4.5 kg significantly reduces the risk of developing type 2 diabetes by approximately 30% in overweight individuals with a family history of diabetes, regardless of whether they had normal glucose tolerance or impaired glucose tolerance at baseline.
If you are overweight and have a family history of diabetes, you do not need to achieve massive weight loss to significantly lower your risk. Losing just 4.5 kg (about 10 lbs) can reduce your risk of developing type 2 diabetes by roughly 30%. This benefit applies whether your blood sugar is currently normal or slightly impaired. Focus on achieving this modest loss, as it provides substantial protection even if you struggle to maintain it long-term.
in all treatment groups, a modest weight loss of 4.5 kg reduced the risk of type 2 diabetes by ~30% compared with no weight loss.
Why this rating
Randomized controlled trial with 154 participants, though long-term maintenance of lifestyle changes was poor.
Source
Lifestyle Intervention in Overweight Individuals With a Family History of Diabetes
Rena R. Wing et al. · Diabetes Care · 1998
DOI 10.2337/diacare.21.3.350
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