Mixed
Higher genetically predicted fat mass index is strongly associated with an increased risk of aortic valve stenosis, with the strongest magnitude of association observed among all cardiovascular conditions studied.
Reducing fat mass is particularly important for preventing aortic valve stenosis, as it shows the strongest association among all cardiovascular conditions studied. Focus on fat loss strategies, such as caloric deficit and aerobic exercise, to specifically target fat mass reduction for better heart valve health.
The strongest magnitude of association was with aortic valve stenosis (OR per 1 kg/m2 increase in fat mass index 1.46, 95% CI 1.13–1.88; P = 3.9 (cid:2) 10-3).
Why this rating
MR design provides strong causal inference; the association is statistically significant and robust.
Source
Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study
Susanna C. Larsson et al. · European Heart Journal · 2019
DOI 10.1093/eurheartj/ehz388
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- Higher genetically predicted body mass index (BMI) and fat mass index causally increase the risk of aortic valve stenosis, heart failure, deep vein thrombosis, arterial hypertension, peripheral artery disease, coronary artery disease, atrial fibrillation, and pulmonary embolism.Good
- Higher genetically predicted fat-free mass index is inversely associated with the risk of atrial fibrillation, ischaemic stroke, and abdominal aortic aneurysm.Moderate
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