Mixed
Higher genetically predicted fat-free mass index is inversely associated with the risk of atrial fibrillation, ischaemic stroke, and abdominal aortic aneurysm.
Maintaining or increasing fat-free mass (muscle) may offer protective benefits against atrial fibrillation, ischaemic stroke, and abdominal aortic aneurysm. Incorporate resistance training to build muscle, while also managing fat mass to optimize cardiovascular health.
There was significant or suggestive evidence that genetically predicted fat-free mass index was inversely associated with atrial fibrillation, ischaemic stroke, and abdominal aortic aneurysm.
Why this rating
MR design provides causal inference, but the associations are described as 'significant or suggestive', indicating some uncertainty.
Source
Body mass index and body composition in relation to 14 cardiovascular conditions in UK Biobank: a Mendelian randomization study
Susanna C. Larsson et al. · European Heart Journal · 2019
DOI 10.1093/eurheartj/ehz388
More from this paper
- Higher genetically predicted body mass index (BMI) and fat mass index causally increase the risk of aortic valve stenosis, heart failure, deep vein thrombosis, arterial hypertension, peripheral artery disease, coronary artery disease, atrial fibrillation, and pulmonary embolism.Good
- Higher genetically predicted fat mass index is strongly associated with an increased risk of aortic valve stenosis, with the strongest magnitude of association observed among all cardiovascular conditions studied.Good
Related findings · Mixed
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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