Hormonal
Pharmacological inhibition of mTOR via rapamycin extends lifespan across multiple model organisms, including yeast, nematodes, fruit flies, and mice.
This paper establishes that inhibiting the mTOR pathway, specifically via rapamycin, extends lifespan in various animals. While this is a key finding in longevity research, the paper notes that translating this to humans requires understanding the complex interplay with nutrient sensing and potential side effects, as rapamycin is an immunosuppressant.
Pharmacological inhibition of TOR by rapamycin in S. cerevisiae, C. elegans, D. melanogaster, or Mus musculus confirmed the evolutionary conserved and fundamental role of mTOR as a regulator of longevity
Why this rating
The claim is supported by extensive evidence across multiple evolutionary conserved species cited in the review.
Source
mTOR as a central regulator of lifespan and aging
David Papadopoli et al. · F1000Research · 2019
DOI 10.12688/f1000research.17196.1
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- Caloric restriction (CR) and dietary restriction (DR) extend lifespan and healthspan, largely by suppressing the IIS/mTOR axis, although CR may also act through mTOR-independent mechanisms.Strong
- Protein restriction (PR) and specific amino acid restrictions (e.g., methionine, BCAAs) improve metabolic health and extend lifespan/healthspan, likely mediated by mTOR inhibition.Good
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