Research
Macro partitioning
Protein restriction (PR) and specific amino acid restrictions (e.g., methionine, BCAAs) improve metabolic health and extend lifespan/healthspan, likely mediated by mTOR inhibition.
Restricting protein intake, or specific amino acids like methionine or BCAAs, can improve metabolic health and extend lifespan in mice, and is linked to better health outcomes in humans. This suggests that optimizing protein quality and quantity, rather than maximizing it, may be beneficial for longevity.
GoodSupportsHIGH confidence
one of the most effective interventions appears to be the reduction of protein and amino acid intake (protein restriction, or PR) ... PR extends both life span and health span in mice but was linked to reductions in cancer, diabetes, and overall mortality in humans
Why this rating
Supported by studies in mice and human epidemiological data linking PR to reduced mortality and disease.
Source
mTOR as a central regulator of lifespan and aging
David Papadopoli et al. · F1000Research · 2019
DOI 10.12688/f1000research.17196.1
narrative_reviewCited 434×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Caloric restriction (CR) and dietary restriction (DR) extend lifespan and healthspan, largely by suppressing the IIS/mTOR axis, although CR may also act through mTOR-independent mechanisms.Strong
- Pharmacological inhibition of mTOR via rapamycin extends lifespan across multiple model organisms, including yeast, nematodes, fruit flies, and mice.Good
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