Macro partitioning
Caloric restriction (CR) and dietary restriction (DR) extend lifespan and healthspan, largely by suppressing the IIS/mTOR axis, although CR may also act through mTOR-independent mechanisms.
Reducing calorie intake by 20-40% or restricting specific nutrients like protein or methionine can extend lifespan and healthspan in model organisms. This works partly by suppressing the mTOR pathway, but also through other mechanisms. For humans, this suggests that mindful eating, potentially focusing on protein quality and quantity, may offer longevity benefits.
Suppression of the IIS/mTOR axis is thought to be one of the underpinning mechanisms of the beneficiary effects of dietary restriction (DR), which not only prolongs life span but also delays the onset of age-related pathologies (commonly referred to as health span) across a variety of organisms
Why this rating
Supported by numerous studies across multiple species including yeast, nematodes, flies, rats, mice, and primates.
Source
mTOR as a central regulator of lifespan and aging
David Papadopoli et al. · F1000Research · 2019
DOI 10.12688/f1000research.17196.1
More from this paper
- Pharmacological inhibition of mTOR via rapamycin extends lifespan across multiple model organisms, including yeast, nematodes, fruit flies, and mice.Good
- Protein restriction (PR) and specific amino acid restrictions (e.g., methionine, BCAAs) improve metabolic health and extend lifespan/healthspan, likely mediated by mTOR inhibition.Good
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