Research
Hormonal
Loss of ovarian function (menopause) causes obesity and metabolic dysfunction primarily through reduced energy expenditure and increased adipose tissue inflammation, independent of increased food intake.
Postmenopausal weight gain is not just about eating more; your body burns fewer calories at rest. Focus on strategies that support metabolic rate and manage inflammation, rather than assuming the issue is solely caloric intake.
GoodSupportsHIGH confidence
OVX in mice decreases energy expenditure, without altering energy intake, resulting in adipocyte hypertrophy, adipose tissue inflammation, and hepatic steatosis.
Why this rating
High-quality controlled animal study with pair-feeding controls to isolate metabolic effects from hyperphagia.
Source
Reduced Energy Expenditure and Increased Inflammation Are Early Events in the Development of Ovariectomy-Induced Obesity
Nicole H. Rogers et al. · Endocrinology · 2009
DOI 10.1210/en.2008-1405
mechanism_onlyCited 419×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Ovariectomy induces visceral adipose tissue inflammation characterized by T-cell infiltration and M1 macrophage polarization, which contributes to insulin resistance.Good
- Ovariectomy leads to hepatic steatosis (fatty liver) driven by upregulation of PPAR-gamma and lipogenic genes, independent of dietary fat intake.Good
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