Research
Hormonal
Ovariectomy leads to hepatic steatosis (fatty liver) driven by upregulation of PPAR-gamma and lipogenic genes, independent of dietary fat intake.
Menopause increases the risk of fatty liver disease through hormonal changes that activate fat-producing genes in the liver, even without eating more fat.
GoodSupportsHIGH confidence
histology revealed OVX-specific liver hepatic steatosis, coincident with increased PPAR-gamma gene expression and downstream lipogenic gene expression.
Why this rating
Clear histological and molecular evidence of liver pathology.
Source
Reduced Energy Expenditure and Increased Inflammation Are Early Events in the Development of Ovariectomy-Induced Obesity
Nicole H. Rogers et al. · Endocrinology · 2009
DOI 10.1210/en.2008-1405
mechanism_onlyCited 419×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Loss of ovarian function (menopause) causes obesity and metabolic dysfunction primarily through reduced energy expenditure and increased adipose tissue inflammation, independent of increased food intake.Good
- Ovariectomy induces visceral adipose tissue inflammation characterized by T-cell infiltration and M1 macrophage polarization, which contributes to insulin resistance.Good
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