Research
Hormonal
Ovariectomy induces visceral adipose tissue inflammation characterized by T-cell infiltration and M1 macrophage polarization, which contributes to insulin resistance.
Visceral fat becomes inflamed after menopause due to immune cell infiltration. This inflammation drives insulin resistance, suggesting anti-inflammatory strategies may be beneficial.
GoodSupportsHIGH confidence
OVX mice displayed evidence of immune infiltration and inflammation in adipose tissue, because perigonadal and inguinal adipose depots from OVX mice had increased expression of TNF-alpha, iNOS, CD11c, and other hallmarks of adipose tissue inflammation.
Why this rating
Detailed molecular and histological analysis of inflammatory markers.
Source
Reduced Energy Expenditure and Increased Inflammation Are Early Events in the Development of Ovariectomy-Induced Obesity
Nicole H. Rogers et al. · Endocrinology · 2009
DOI 10.1210/en.2008-1405
mechanism_onlyCited 419×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Loss of ovarian function (menopause) causes obesity and metabolic dysfunction primarily through reduced energy expenditure and increased adipose tissue inflammation, independent of increased food intake.Good
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