Mixed
Oral administration of Akkermansia muciniphila (2x10^8 bacterial cells/day) reverses high-fat diet-induced obesity and metabolic disorders in mice by improving gut barrier function and lipid metabolism without altering food intake.
If you are struggling with obesity or metabolic issues, increasing your levels of Akkermansia muciniphila through diet (prebiotic fibers, polyphenols) or supplementation may help improve your gut barrier and lipid metabolism. Note that this benefit is most pronounced if you have existing metabolic disorders like those induced by a high-fat diet.
Oral administration of A. muciniphila at the dose of 2 × 108 bacterial cells per day could reverse HFD-induced obesity in mice by mediating adipocyte metabolism and gut barrier function without influencing food intake (Cani and de Vos, 2017).
Why this rating
Supported by multiple animal models and some human studies, but largely preclinical.
Source
Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems
Yu Xu et al. · Frontiers in Microbiology · 2020
DOI 10.3389/fmicb.2020.00219
More from this paper
- Akkermansia muciniphila abundance is inversely correlated with obesity and metabolic syndrome severity in humans, and its enrichment can serve as an indicator of metabolic health.Good
- Dietary interventions, including calorie restriction, prebiotic fibers, and polyphenols, increase the abundance of Akkermansia muciniphila in the gut.Good
Related findings · Mixed
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