Research
Energy balance
Maintaining mitochondrial dynamics (balance of fission and fusion) and quality control (mitophagy/biogenesis) is critical for preventing age-related metabolic diseases and neurodegeneration.
Support mitochondrial quality control through regular physical activity, which naturally stimulates mitophagy and biogenesis. Focus on metabolic health (insulin sensitivity) to support the energy demands of these processes.
GoodSupportsHIGH confidence
Dysfunctional or stressed mitochondria generate signals that act to protect against cell death... Therapeutic strategies that improve mitochondrial dysfunction by targeting mitochondrial dynamics, quality control and stress response-mediated mitohormesis pathways may benefit humans
Why this rating
Strong evidence from genetic models (knockouts/knockdowns) linking specific proteins (Mfn2, Drp1) to metabolic disease.
Source
The Mitochondrial Basis of Aging and Age-Related Disorders
Sarika Srivastava · Genes · 2017
DOI 10.3390/genes8120398
narrative_reviewCited 412×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Mitochondrial dysfunction, driven by the accumulation of somatic mtDNA mutations and altered dynamics (fission/fusion imbalance), is a primary hallmark and causal driver of aging and age-related pathologies, rather than merely a consequence.Good
- Reactive Oxygen Species (ROS) are not the primary cause of aging; instead, they are a consequence of mitochondrial dysfunction, and moderate ROS increases can extend lifespan via mitohormesis.Good
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