Mixed
Exogenous environmental factors, including diet, stress, and exercise, induce direct or indirect epigenetic modifications (DNA methylation, histone modification, RNA silencing) that can permanently alter gene expression profiles and influence health outcomes across the human lifespan.
Your lifestyle choices (diet, stress management, exercise) are not just temporary fixes; they chemically tag your DNA and histones, potentially altering gene expression for the long term. While you cannot change your DNA sequence, you can influence how those genes are read through consistent environmental inputs, particularly during critical developmental windows and throughout adulthood.
exposure to pharmaceutical and toxic chemicals, diet, stress, exercise, and other environmental factors are capable of eliciting positive or negative epigenetic modifications with lasting effects on development, metabolism and health. These can impact the body so profoundly as to permanently alter the epigenetic profile of an individual.
Why this rating
This is a review article proposing hypotheses and summarizing animal/human studies; it is not a primary clinical trial.
Source
Epigenetics across the human lifespan
Riya R. Kanherkar et al. · Frontiers in Cell and Developmental Biology · 2014
DOI 10.3389/fcell.2014.00049
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