Research
Micronutrients & recovery
Curcumin, a dietary polyphenol, acts as both a direct and indirect epigenetic factor by inhibiting Histone acetyltransferase p300/CBP and GATA4, reducing nuclear acetylation and myocardial cell hypertrophy.
Curcumin inhibits enzymes that promote histone acetylation and cell hypertrophy. While mechanistic data exists, specific dosing protocols for humans are not provided in this review.
ModerateSupportsMEDIUM confidence
curcumin... is an inhibitor of the Histone acetlytransferase p300/CBP (co-activator) and GATA4 (a zinc finger transcription factor), which leads to decrease in nuclear acetylation induced during myocardial cell hypertrophy
Why this rating
Cited study (Morimoto et al., 2008) is likely preclinical.
Source
Epigenetics across the human lifespan
Riya R. Kanherkar et al. · Frontiers in Cell and Developmental Biology · 2014
narrative_reviewCited 406×
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