Research
Micronutrients & recovery
Curcumin, a dietary polyphenol, acts as both a direct and indirect epigenetic factor by inhibiting Histone acetyltransferase p300/CBP and GATA4, reducing nuclear acetylation and myocardial cell hypertrophy.
Curcumin inhibits enzymes that promote histone acetylation and cell hypertrophy. While mechanistic data exists, specific dosing protocols for humans are not provided in this review.
ModerateSupportsMEDIUM confidence
curcumin... is an inhibitor of the Histone acetlytransferase p300/CBP (co-activator) and GATA4 (a zinc finger transcription factor), which leads to decrease in nuclear acetylation induced during myocardial cell hypertrophy
Why this rating
Cited study (Morimoto et al., 2008) is likely preclinical.
Source
Epigenetics across the human lifespan
Riya R. Kanherkar et al. · Frontiers in Cell and Developmental Biology · 2014
DOI 10.3389/fcell.2014.00049
narrative_reviewCited 406×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Exogenous environmental factors, including diet, stress, and exercise, induce direct or indirect epigenetic modifications (DNA methylation, histone modification, RNA silencing) that can permanently alter gene expression profiles and influence health outcomes across the human lifespan.Moderate
- Caloric restriction (30-50% reduction) acts as a direct epigenetic factor by decreasing histone deacetylase 2 (HDAC2) levels, thereby delaying aging and alleviating age-related diseases in animal models.Moderate
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