Research
Mixed
Administration of insulin-sensitivity-associated bacteria, specifically Alistipes indistinctus, ameliorates insulin resistance and improves glucose tolerance in high-fat diet-fed mice by reducing caecal monosaccharide levels.
Specific gut bacteria, such as Alistipes indistinctus, can help break down harmful sugars in the gut, potentially improving insulin sensitivity. This suggests that targeting specific bacterial strains could be a therapeutic strategy for metabolic health.
GoodSupportsHIGH confidence
We identify gut bacteria associated with insulin resistance and insulin sensitivity that show a distinct pattern of carbohydrate metabolism, and demonstrate that insulin-sensitivity-associated bacteria ameliorate host phenotypes of insulin resistance in a mouse model.
Why this rating
Robust experimental design with multiple bacterial strains and metabolic measurements.
Source
Gut microbial carbohydrate metabolism contributes to insulin resistance
Tadashi Takeuchi et al. · Nature · 2023
DOI 10.1038/s41586-023-06466-x
cohort · n=306Cited 403×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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