Micronutrients & recovery
Direct supplementation with Urolithin A (UA) improves skeletal muscle mitochondrial function and health span in elderly humans, bypassing the need for gut microbiome conversion of dietary precursors.
If you are over 60 and interested in supporting muscle health and mitochondrial function, direct Urolithin A supplementation is a viable option, especially if you do not naturally produce it from your diet. The first human trials show it is safe and improves muscle biomarkers. You do not need to rely on eating pomegranates or berries, as your gut may no longer convert them effectively.
In humans, benefits of UA supplementation in the muscle are supported by recent clinical trials in elderly people. ... Data from the first-in-human Phase I trial with UA administration showed a decrease in several plasma acylcarnitines ... and an increase in the expression of mitochondrial gene sets in the muscle.
Why this rating
Strong preclinical data across species and a confirmed Phase I human trial showing safety and biomarker improvements, though long-term clinical outcomes are not yet detailed.
Source
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
Davide D’Amico et al. · Trends in Molecular Medicine · 2021
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