Research
Micronutrients & recovery
Urolithin A extends lifespan and improves muscle function in preclinical models by activating mitophagy and reducing inflammation.
This node describes animal studies. While it confirms the biological plausibility of UA's benefits, it does not directly translate to a human dosing protocol. It supports the use of UA in humans as described in Node 1.
StrongSupportsHIGH confidence
UA extends lifespan by 45% [in C. elegans] ... UA treatment significantly increased the survival rate of the mdx/Utr−/− double knockout (DKO) mouse model of DMD ... UA was administered in the diet ... Mice showed enhanced skeletal muscle strength ... and better aerobic performance
Why this rating
Consistent findings across multiple species (worms, mice, rats) and multiple disease models (DMD, AD, colitis).
Source
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
Davide D’Amico et al. · Trends in Molecular Medicine · 2021
DOI 10.1016/j.molmed.2021.04.009
narrative_reviewCited 388×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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