Micronutrients & recovery
The kynurenine/tryptophan (Kyn/Trp) ratio in blood serves as a robust biomarker for the rate of physiological aging (inflammaging) and predicts age-related diseases and mortality.
You can monitor your Kyn/Trp ratio as a blood test to assess your biological aging rate and risk for age-related diseases. A higher ratio indicates increased inflammatory activity associated with aging. This is a diagnostic tool, not a treatment, but it helps identify who might benefit from lifestyle interventions targeting inflammation.
The Kyn/Trp ratio, measured in blood, is robustly associated with aging in humans... implies that the age-dependent increase in the Kyn/Trp ratio is not secondary to the onset of disease but rather represents a physiological age-related change.
Why this rating
Supported by multiple observational human studies cited in the review showing association with frailty, cognitive performance, and mortality.
Source
Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target
Freek J. H. Sorgdrager et al. · Frontiers in Immunology · 2019
DOI 10.3389/fimmu.2019.02565
More from this paper
- Activation of the kynurenine pathway via IDO/TDO enzymes during inflammation promotes immune tolerance and prevents hyperinflammation by depleting tryptophan and producing kynurenine, which activates the aryl hydrocarbon receptor (AhR) to drive regulatory T cell differentiation.Moderate
- Targeting tryptophan metabolism, specifically by inhibiting TDO or boosting de novo NAD+ synthesis, may extend lifespan and improve metabolic health in animal models.Moderate
Related findings · Micronutrients & recovery
- Trans fats (industrial trans-fatty acids) are unequivocally harmful and should be completely avoided as they raise LDL-C, TGs, and Apo B while lowering HDL-C.Strong
- For menopausal women with osteoporosis, first-line pharmacologic therapies include alendronate, risedronate, zoledronic acid, and denosumab for the prevention of hip, nonvertebral, and vertebral fractures.Strong
- Folic acid fortification of flour prevents neural tube birth defects, and mandatory fortification is more effective than voluntary supplementation alone.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →