Micronutrients & recovery
Targeting tryptophan metabolism, specifically by inhibiting TDO or boosting de novo NAD+ synthesis, may extend lifespan and improve metabolic health in animal models.
Current research suggests that modulating tryptophan metabolism (e.g., boosting NAD+ synthesis) might improve metabolic health and potentially extend lifespan in animals. However, this is not yet a recommended human intervention due to potential risks like aggravated inflammation. Focus on healthy lifestyle factors that naturally support metabolic health.
Evidence from studies in Caenorhabditis elegans and rodents suggests that targeting Trp metabolism could extend lifespan... knockdown of tdo-2 in C. elegans increased lifespan with ~15%.
Why this rating
Based on animal studies (C. elegans, mice, rats) and observational data in humans, but no direct human lifespan extension trials.
Source
Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target
Freek J. H. Sorgdrager et al. · Frontiers in Immunology · 2019
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