Research
Hormonal
Sirtuins (SIRTs) are potential therapeutic targets for NAFLD treatment, with SIRT1 playing a key role in regulating lipid metabolism and autophagy.
Sirtuins are being studied as potential drug targets for NAFLD, but no specific sirtuin-activating supplements or drugs are currently recommended for treatment.
ModerateQualifiesMEDIUM confidence
The mechanisms for the pathogenesis of NAFLD, current interventions in the management of the disease, and the role of sirtuins as potential targets for treatment are discussed here.
Why this rating
Based on mechanistic studies and animal models, with limited human clinical data.
Source
NAFLD: Mechanisms, Treatments, and Biomarkers
Fatiha Nassir · Biomolecules · 2022
DOI 10.3390/biom12060824
narrative_reviewCited 376×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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