Research
Energy balance
Lifestyle interventions combining calorie restriction and moderate-intensity exercise are the primary recommended treatment for NAFLD, with weight loss of >7% body weight improving NASH histology and ~10% weight loss leading to fibrosis regression in 45% of patients.
Focus on losing 7-10% of your body weight through a combination of eating fewer calories and doing moderate exercise. This is the most effective way to improve liver health and potentially reverse fibrosis. Even if you don't lose all the weight, regular exercise alone can reduce liver fat.
GoodSupportsHIGH confidence
It is now recognized that a 5% weight reduction is associated with reduced liver fat and improved liver injury while body weight loss of >7% body weight improved NASH based on histology... Among patients who lost ~10% body weight, 90% showed improved NASH, and about ~45% showed fibrosis regression... A combination of hypocaloric diet and moderate-intensity exercise is likely to result in sustained weight loss over time.
Why this rating
Based on multiple clinical trials and practice guidance cited, though sustained adherence is difficult.
Source
NAFLD: Mechanisms, Treatments, and Biomarkers
Fatiha Nassir · Biomolecules · 2022
DOI 10.3390/biom12060824
narrative_reviewCited 376×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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