Research
Energy balance
Mitochondrial dysfunction, including impaired beta-oxidation and increased ROS production, is a major contributing factor to NAFLD progression.
Healthy mitochondria are crucial for liver health. Exercise and weight loss help improve mitochondrial function, which may reduce liver damage.
GoodSupportsHIGH confidence
Accumulating evidence suggests that changes in mitochondrial function may be a major contributing factor... Multiple mitochondria-associated factors contribute to the development and progression of NAFLD, including reduced beta-oxidation, impaired ETC and ATP depletion, over-production of ROS, oxidative stress-mediated cell damage, and ultra-structural mitochondrial changes.
Why this rating
Strong mechanistic evidence from human and animal studies.
Source
NAFLD: Mechanisms, Treatments, and Biomarkers
Fatiha Nassir · Biomolecules · 2022
DOI 10.3390/biom12060824
narrative_reviewCited 376×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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