Research
Hormonal
PGC-1α regulates mitochondrial quality control mechanisms, including fission, fusion, and mitophagy, which impacts age-related mitochondrial dysfunction and insulin sensitivity.
Focus on exercises that stimulate PGC-1α, such as endurance training, to support mitochondrial quality control, not just volume. This may help maintain metabolic health and insulin sensitivity as you age.
GoodSupportsHIGH confidence
PGC-1α regulates mitochondrial biogenesis, but also has effects on mitochondrial functions beyond biogenesis. Mitochondrial quality control mechanisms, including fission, fusion and mitophagy, are regulated by PGC-1α. PGC-1α-mediated regulation of mitochondrial quality may affect age-related mitochondrial dysfunction and insulin sensitivity.
Why this rating
Based on multiple mouse models and human studies, though some conflicting results exist.
Source
PGC-1α-mediated regulation of mitochondrial function and physiological implications
Jens Frey Halling et al. · Applied Physiology Nutrition and Metabolism · 2020
DOI 10.1139/apnm-2020-0005
narrative_reviewCited 364×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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