Research
Hormonal
PGC-1α regulates ANT1 protein content, which influences submaximal ADP-stimulated respiration and intrinsic mitochondrial function.
Maintaining PGC-1α levels through exercise may support efficient energy exchange in mitochondria, potentially improving metabolic efficiency.
GoodSupportsHIGH confidence
Taken together, PGC-1α regulates ANT1 protein as well as submaximal respiration in mouse skeletal muscle. This provides evidence for PGC-1α-mediated regulation of mitochondrial ADP sensitivity through regulation of ANT1-dependent ADP/ATP exchange.
Why this rating
Supported by multiple studies using different mouse models.
Source
PGC-1α-mediated regulation of mitochondrial function and physiological implications
Jens Frey Halling et al. · Applied Physiology Nutrition and Metabolism · 2020
DOI 10.1139/apnm-2020-0005
narrative_reviewCited 364×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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