Research
Hormonal
PGC-1α plays an important role in skeletal muscle ROS balance through the regulation of anti-oxidant proteins and proton leak.
Exercise that boosts PGC-1α may help manage oxidative stress by enhancing anti-oxidant defenses and reducing proton leak.
GoodSupportsHIGH confidence
Taken together, PGC-1α plays an important role in skeletal muscle ROS balance through the regulation of anti-oxidant proteins, but likely also through direct effects on mitochondrial proton leak and ROS production.
Why this rating
Supported by multiple studies using different mouse models.
Source
PGC-1α-mediated regulation of mitochondrial function and physiological implications
Jens Frey Halling et al. · Applied Physiology Nutrition and Metabolism · 2020
DOI 10.1139/apnm-2020-0005
narrative_reviewCited 364×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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