Research
Micronutrients & recovery
Nutritional ketosis, induced by carbohydrate restriction or caloric restriction, reduces systemic inflammation and ASCVD risk markers primarily through the ketone body beta-hydroxybutyrate (BHB) inhibiting the NLRP3 inflammasome.
If you have insulin resistance, reducing refined carbohydrates can trigger ketone production. This helps lower inflammation by blocking specific immune sensors (NLRP3), offering cardiovascular protection beyond just weight loss.
GoodSupportsHIGH confidence
Mechanistically, reduced inflammation has been linked to the ketone body ß-hydroxybutyrate (BHB)... BHB blocks an innate immune sensor, the NLRP3 inflammasome, with downstream effects resulting in reduced levels of interleukin 1 beta (IL-1b).
Why this rating
Supported by mechanistic studies and references to CANTOS trial for IL-1b inhibition.
Source
Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors
Katharina Lechner et al. · European Journal of Preventive Cardiology · 2019
DOI 10.1177/2047487319869400
narrative_reviewCited 360×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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